EVALUATION OF THE IMPORTANCE OF HYDROPHOBIC INTERACTIONS IN DRUG-BINDING TO DIHYDROFOLATE-REDUCTASE

被引:96
作者
TAIRA, K
BENKOVIC, SJ
机构
[1] PENN STATE UNIV, DEPT CHEM, 152 DAVEY LAB, UNIVERSITY PK, PA 16802 USA
[2] MINIST INT TRADE & IND, AGCY IND SCI & TECHNOL, FERMENTAT RES INST, Tsukuba, IBARAKI 305, JAPAN
关键词
D O I
10.1021/jm00396a019
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:129 / 137
页数:9
相关论文
共 65 条
[1]   COOPERATIVITY IN LIGAND-BINDING TO DIHYDROFOLATE-REDUCTASE [J].
BIRDSALL, B ;
BURGEN, ASV ;
MIRANDA, JRD ;
ROBERTS, GCK .
BIOCHEMISTRY, 1978, 17 (11) :2102-2110
[2]   BINDING OF COENZYME ANALOGS TO LACTOBACILLUS-CASEI DIHYDROFOLATE-REDUCTASE - BINARY AND TERNARY COMPLEXES [J].
BIRDSALL, B ;
BURGEN, ASV ;
ROBERTS, GCK .
BIOCHEMISTRY, 1980, 19 (16) :3723-3731
[3]   ROLE OF ISOMERIZATION OF INITIAL COMPLEXES IN THE BINDING OF INHIBITORS TO DIHYDROFOLATE-REDUCTASE [J].
BLAKLEY, RL ;
COCCO, L .
BIOCHEMISTRY, 1985, 24 (18) :4772-4777
[4]   CRYSTALLINE DIHYDROPTEROYLGLUTAMIC ACID [J].
BLAKLEY, RL .
NATURE, 1960, 188 (4746) :231-232
[5]  
BLAKLEY RL, 1985, BIOCHEMISTRY-US, V24, P4704, DOI 10.1021/bi00338a032
[6]  
BLAKLEY RL, 1985, FOLATES PTERINS, P191
[7]   STRUCTURE ACTIVITY RELATIONSHIPS OF DIHYDROFOLATE-REDUCTASE INHIBITORS [J].
BLANEY, JM ;
HANSCH, C ;
SILIPO, C ;
VITTORIA, A .
CHEMICAL REVIEWS, 1984, 84 (04) :333-407
[8]  
BOLIN JT, 1982, J BIOL CHEM, V257, P13650
[9]   PTERIDINE STUDIES .14. METHYLATION OF 2-AMINO-4-HYDROXYPTERIDINE AND RELTED COMPOUNDS [J].
BROWN, DJ ;
JACOBSEN, NW .
JOURNAL OF THE CHEMICAL SOCIETY, 1961, (OCT) :4413-&
[10]   AROMATIC-AROMATIC INTERACTION - A MECHANISM OF PROTEIN-STRUCTURE STABILIZATION [J].
BURLEY, SK ;
PETSKO, GA .
SCIENCE, 1985, 229 (4708) :23-28