TAXOL - THE CHEMISTRY AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF A NOVEL ANTICANCER AGENT

被引：143

作者：

KINGSTON, DGI

机构：

[1] Department of Chemistry, Virginia Polytechnic Institute, State University, Blacksburg

来源：

TRENDS IN BIOTECHNOLOGY | 1994年 / 12卷 / 06期

关键词：

D O I：

10.1016/0167-7799(94)90120-1

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Taxol is an exciting new anticancer drug, showing clinical activity against ovarian and breast cancer. Its development as a clinically useful drug has involved major efforts to overcome the supply problem; this has now been done, and the focus of interest has moved to the development of improved analogs of the drug. Recent notable achievements include the first total synthesis of taxol, and the first indications of its binding site on tubulin.

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页码：222 / 227

页数：6

相关论文

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