LOCALIZATION OF NON-N-METHYL-D-ASPARTATE GLUTAMATE RECEPTORS IN NORMAL AND ALZHEIMER HIPPOCAMPAL-FORMATION

被引:26
作者
HYMAN, BT [1 ]
PENNEY, JB [1 ]
BLACKSTONE, CD [1 ]
YOUNG, AB [1 ]
机构
[1] JOHNS HOPKINS UNIV, SCH MED, DEPT NEUROSCI, BALTIMORE, MD 21205 USA
关键词
D O I
10.1002/ana.410350106
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The hippocampi and adjacent temporal cortices of 24 human brains were examined with antibodies to the GluR1, GluR2/3, and GluR4 subunits of the D,L-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-preferring glutamate receptor. GluR1 immunoreactivity was most dense in the dentate gyrus, with lower densities in other hippocampal and cortical regions. GluR2/3 immunoreactivity was the most intense of the three antibodies, with high levels throughout most hippocampal subfields; where it was localized to cell bodies, proximal axons, and dendrites. GluR4 immunoreactivity was very sparse in all regions. In Alzheimer's disease brains, the general pattern of staining was similar to that seen in control brains. GluR1 and GluR4 immunoreactivity was seen in some but not all neuritic plaques. All three antibodies recognized some neurons undergoing neurofibrillary degeneration.
引用
收藏
页码:31 / 37
页数:7
相关论文
共 38 条
[11]  
Foster A C, 1990, Adv Neurol, V51, P97
[12]   THE ROLE OF GLUTAMATE IN NEUROTRANSMISSION AND IN NEUROLOGIC DISEASE [J].
GREENAMYRE, JT .
ARCHIVES OF NEUROLOGY, 1986, 43 (10) :1058-1063
[13]   EXCITATORY AMINO-ACIDS AND ALZHEIMERS-DISEASE [J].
GREENAMYRE, JT ;
YOUNG, AB .
NEUROBIOLOGY OF AGING, 1989, 10 (05) :593-602
[14]   CLONING BY FUNCTIONAL EXPRESSION OF A MEMBER OF THE GLUTAMATE RECEPTOR FAMILY [J].
HOLLMANN, M ;
OSHEAGREENFIELD, A ;
ROGERS, SW ;
HEINEMANN, S .
NATURE, 1989, 342 (6250) :643-648
[15]   CA2+ PERMEABILITY OF KA-AMPA GATED GLUTAMATE RECEPTOR CHANNELS DEPENDS ON SUBUNIT COMPOSITION [J].
HOLLMANN, M ;
HARTLEY, M ;
HEINEMANN, S .
SCIENCE, 1991, 252 (5007) :851-853
[16]   IDENTIFICATION OF A SITE IN GLUTAMATE RECEPTOR SUBUNITS THAT CONTROLS CALCIUM PERMEABILITY [J].
HUME, RI ;
DINGLEDINE, R ;
HEINEMANN, SF .
SCIENCE, 1991, 253 (5023) :1028-1031
[17]   ALZHEIMERS-DISEASE - GLUTAMATE DEPLETION IN THE HIPPOCAMPAL PERFORANT PATHWAY ZONE [J].
HYMAN, BT ;
VANHOESEN, GW ;
DAMASIO, AR .
ANNALS OF NEUROLOGY, 1987, 22 (01) :37-40
[18]   EXCITATORY AMINO-ACID RECEPTORS IN THE HUMAN CEREBRAL-CORTEX - A QUANTITATIVE AUTORADIOGRAPHIC STUDY COMPARING THE DISTRIBUTIONS OF [H-3]TCP, [H-3] GLYCINE, L-[H-3]GLUTAMATE, [H-3] AMPA AND [H-3] KAINIC ACID BINDING-SITES [J].
JANSEN, KLR ;
FAULL, RLM ;
DRAGUNOW, M .
NEUROSCIENCE, 1989, 32 (03) :587-607
[19]   A FAMILY OF AMPA-SELECTIVE GLUTAMATE RECEPTORS [J].
KEINANEN, K ;
WISDEN, W ;
SOMMER, B ;
WERNER, P ;
HERB, A ;
VERDOORN, TA ;
SAKMANN, B ;
SEEBURG, PH .
SCIENCE, 1990, 249 (4968) :556-560
[20]   DIAGNOSIS OF ALZHEIMERS-DISEASE [J].
KHACHATURIAN, ZS .
ARCHIVES OF NEUROLOGY, 1985, 42 (11) :1097-1104