FURTHER BROMINATED BIS-INDOLE AND TRIS-INDOLE ALKALOIDS FROM THE DEEP-WATER NEW-CALEDONIAN MARINE SPONGE ORINA SP

被引:193
作者
BIFULCO, G
BRUNO, I
RICCIO, R
LAVAYRE, J
BOURDY, G
机构
[1] UNIV NAPLES FEDERICO II,DIPARTIMENTO CHIM SOSTANZE NAT,I-80131 NAPLES,ITALY
[2] RHONE POULENC RORER SA,CTR RECH VITRY ALFORTVILLE,F-94403 VITRY,FRANCE
[3] ORSTOM,NOUMEA,NEW CALEDONIA
来源
JOURNAL OF NATURAL PRODUCTS-LLOYDIA | 1995年 / 58卷 / 08期
关键词
D O I
10.1021/np50122a017
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Two tris-indole alkaloids, (+/-)-gelliusines A and B [1], have been isolated for the first time from a marine source, the New Caledonian sponge, Orina sp. (or Gellius sp.), along with five further indole constituents [2-6]. Compound 6 has been identified as 2,2-bis-(6'-bromo-3'-indolyl)-ethylamine, previously isolated from the tunicate Didemnum candidum, but the remaining four indoles [2-5] are novel compounds. These showed anti-serotonin activity and a strong affinity for somatostatin and neuropeptide Y receptors in receptor-binding assays.
引用
收藏
页码:1254 / 1260
页数:7
相关论文
共 15 条
  • [1] ALVAREZ M, 1991, HETEROCYCLES, V32, P1391
  • [2] (+/-)-GELLIUSINE-A AND (+/-)-GELLIUSINE-B, 2 DIASTEREOMERIC BROMINATED TRIS-INDOLE ALKALOIDS FROM A DEEP-WATER NEW CALEDONIAN MARINE SPONGE (GELLIUS OR ORINA SP)
    BIFULCO, G
    BRUNO, I
    MINALE, L
    RICCIO, R
    CALIGNANO, A
    DEBITUS, C
    [J]. JOURNAL OF NATURAL PRODUCTS, 1994, 57 (09): : 1294 - 1299
  • [3] BROMINATED INDOLE ALKALOIDS FROM THE MARINE TUNICATE PSEUDODISTOMA-ARBORESCENS
    CHBANI, M
    PAIS, M
    DELAUNEUX, JM
    DEBITUS, C
    [J]. JOURNAL OF NATURAL PRODUCTS, 1993, 56 (01): : 99 - 104
  • [4] CHRISTOPHERSEN C, 1985, ALKALOIDS CHEM PHARM, V24, P25
  • [5] 6-BROMOTRYPTAMINE DERIVATIVES FROM THE GULF OF CALIFORNIA TUNICATE DIDEMNUM-CANDIDUM
    FAHY, E
    POTTS, BCM
    FAULKNER, DJ
    SMITH, K
    [J]. JOURNAL OF NATURAL PRODUCTS, 1991, 54 (02): : 564 - 569
  • [6] MARINE NATURAL-PRODUCTS
    FAULKNER, DJ
    [J]. NATURAL PRODUCT REPORTS, 1994, 11 (04) : 355 - 395
  • [7] MARINE NATURAL-PRODUCTS
    FAULKNER, DJ
    [J]. NATURAL PRODUCT REPORTS, 1991, 8 (02) : 97 - 147
  • [8] MARINE NATURAL-PRODUCTS
    FAULKNER, DJ
    [J]. NATURAL PRODUCT REPORTS, 1992, 9 (04) : 323 - 364
  • [9] MARINE NATURAL-PRODUCTS
    FAULKNER, DJ
    [J]. NATURAL PRODUCT REPORTS, 1993, 10 (05) : 497 - 539
  • [10] Hulme E.C., 1992, RECEPTOR LIGAND INTE