CURATIVE EFFECTS OF ALL-TRANS-RETINOIC ACID ON RAT SARCOMAS

被引：1

作者：

FAIDERBE, S ^{[1
]}

CHAGNAUD, JL ^{[1
]}

DESEZE, R ^{[1
]}

GEFFARD, M ^{[1
]}

机构：

[1] CHU NIMES,SERV MED NUCL & BIOPHYS,F-30006 NIMES,FRANCE

来源：

ANTI-CANCER DRUGS | 1992年 / 3卷 / 05期

关键词：

ALL-TRANS-RETINOIC ACID; AUTOANTIBODIES; MAGNETIC RESONANCE IMAGING; SARCOMA; TUMOR GROWTH;

D O I：

10.1097/00001813-199210000-00015

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The effects of all-trans-retinoic acid (all-trans-RA) on benzo(a)pyrene [B(a)P]-induced malignant sarcomas in Sprague-Dawley female rats were evaluated. Ninety-eight days after B(a)P administration, all-trans-RA was dally injected to animals with or without clinically palpable tumors. The growth of tumors was slowed down compared with controls. Magnetic resonance imaging analyses showed that all-trans-RA-treated rat tumors presented early necrotic areas. Animal survival was slightly increased. Anti-phosphatidylinositol autoantibody levels which were significantly higher in B(a)P-treated rat sera were not modified by all-trans-RA treatment.

引用

页码：541 / 547

页数：7

共 34 条

[21]

MENGER H, 1988, BLOOD, V72, P567

[22]

MILLER WH, 1990, ONCOGENE, V5, P511

[23]

MOON RC, 1990, METHOD ENZYMOL, V190, P395

[24] CHEMOPREVENTION OF EXPERIMENTAL CARCINOGENESIS IN ANIMALS [J].

MOON, RC ;

MEHTA, RG .

PREVENTIVE MEDICINE, 1989, 18 (05) :576-591

[25] RETINOIC ACID IS A POTENT INHIBITOR OF INDUCIBLE PIGMENTATION IN MURINE AND HAMSTER MELANOMA CELL-LINES [J].

ORLOW, SJ ;

CHAKRABORTY, AK ;

PAWELEK, JM .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1990, 94 (04) :461-464

[26] RETINOIC ACID-INDUCED DIFFERENTIATION OF CULTURED HUMAN NEURO-BLASTOMA CELLS - A COMPARISON WITH PHORBOLESTER-INDUCED DIFFERENTIATION [J].

PAHLMAN, S ;

RUUSALA, AI ;

ABRAHAMSSON, L ;

MATTSSON, MEK ;

ESSCHER, T .

CELL DIFFERENTIATION, 1984, 14 (02) :135-144

[27] RETINOIC ACID RAPIDLY DECREASES PHOSPHATIDYLINOSITOL TURNOVER DURING NEUROBLASTOMA CELL-DIFFERENTIATION [J].

PONZONI, M ;

LANCIOTTI, M .

JOURNAL OF NEUROCHEMISTRY, 1990, 54 (02) :540-546

[28]

RATKO TA, 1989, CANCER RES, V49, P4472

[29]

ROBERTS A, 1989, CELLULAR BIOL BIOCH, P209

[30]

SIDELL N, 1986, EXP CELL BIOL, V54, P287

← 1 2 3 4 →