CURATIVE EFFECTS OF ALL-TRANS-RETINOIC ACID ON RAT SARCOMAS

被引：1

作者：

FAIDERBE, S ^{[1
]}

CHAGNAUD, JL ^{[1
]}

DESEZE, R ^{[1
]}

GEFFARD, M ^{[1
]}

机构：

[1] CHU NIMES,SERV MED NUCL & BIOPHYS,F-30006 NIMES,FRANCE

来源：

ANTI-CANCER DRUGS | 1992年 / 3卷 / 05期

关键词：

ALL-TRANS-RETINOIC ACID; AUTOANTIBODIES; MAGNETIC RESONANCE IMAGING; SARCOMA; TUMOR GROWTH;

D O I：

10.1097/00001813-199210000-00015

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The effects of all-trans-retinoic acid (all-trans-RA) on benzo(a)pyrene [B(a)P]-induced malignant sarcomas in Sprague-Dawley female rats were evaluated. Ninety-eight days after B(a)P administration, all-trans-RA was dally injected to animals with or without clinically palpable tumors. The growth of tumors was slowed down compared with controls. Magnetic resonance imaging analyses showed that all-trans-RA-treated rat tumors presented early necrotic areas. Animal survival was slightly increased. Anti-phosphatidylinositol autoantibody levels which were significantly higher in B(a)P-treated rat sera were not modified by all-trans-RA treatment.

引用

页码：541 / 547

页数：7