NOVEL INDOLOCARBAZOLE PROTEIN-KINASE-C INHIBITORS WITH IMPROVED BIOCHEMICAL AND PHYSICOCHEMICAL PROPERTIES

被引：34

作者：

KLEINSCHROTH, J

HARTENSTEIN, J

RUDOLPH, C

SCHACHTELE, C

机构：

[1] TUMOR BIOL CTR,D-79108 FREIBURG,GERMANY

[2] GODECKE PRECLIN RES,D-79090 FREIBURG,GERMANY

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 01期

关键词：

D O I：

10.1016/0960-894X(94)00458-R

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Novel lactam and imide indolocarbazoles were synthesized and characterized with respect to inhibition of protein kinase C and other protein kinases. In both series potent and selective PKC inhibitors could be identified. Structure activity relationships are discussed.

引用

页码：55 / 60

页数：6

共 24 条

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