DRASTIC SOLVENT EFFECT ON LIPASE-CATALYZED ENANTIOSELECTIVE HYDROLYSIS OF PROCHIRAL 1,4-DIHYDROPYRIDINES

被引：103

作者：

HIROSE, Y ^{[1
]}

KARIYA, K ^{[1
]}

SASAKI, I ^{[1
]}

KURONO, Y ^{[1
]}

EBIIKE, H ^{[1
]}

ACHIWA, K ^{[1
]}

机构：

[1] UNIV SHIZUOKA,SCH PHARMACEUT SCI,SHIZUOKA 422,JAPAN

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 47期

关键词：

D O I：

10.1016/S0040-4039(00)60861-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two enantiomers of 1,4-dihydropyridine compounds have been obtained with high enantiomeric purity by lipase-catalyzed hydrolysis in organic solvent saturated with water. Enantioselectivity of this reaction is dependent on the solvent used.

引用

页码：7157 / 7160

页数：4

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