SITE-SPECIFIC COMPARISON OF P53 IMMUNOSTAINING IN SQUAMOUS-CELL CARCINOMAS

被引:19
作者
COULTER, LK
WOLBER, R
TRON, VA
机构
[1] VANCOUVER GEN HOSP,DEPT PATHOL,VANCOUVER,BC V5Z 1M9,CANADA
[2] UNIV BRITISH COLUMBIA,CTR HLTH SCI,VANCOUVER,BC,CANADA
关键词
P53; SKIN CANCER; HPV; UV; IMMUNOHISTOCHEMISTRY;
D O I
10.1016/0046-8177(95)90249-X
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
The p53 tamer suppressor gene is believed to be the most commonly mutated gene in human cancer, p53 is thought to function as a negative regulator of the cell cycle, arresting cells in the G1 phase, This study examined the effects of different mutagenic environments on the incidence of p53 overexpression in squamous cell carcinomas (SCCs) from sun exposed and non-sun exposed squamous epithelium, An immunohistochemical analysis was undertaken in an attempt to assay SSC for p53 overexpression, an indirect measure of missense mutant p53. Positive nuclear staining for p53 was observed in 14 of 21 sun exposed SCCs, two of 19 vulvar/perianal SCCs, and 15 of 20 oral cavity SCCs. The number of positive anogenital tumors was low compared with that of both sun exposed (chi-squared, 1 df, P = .0004) and oral (chi-squared, 1 df, P < .0001) sites. It was concluded that p53 protein accumulation is common in sun-exposed cutaneous SCC and oral SCC compared with anogenital SCC, and thus it is hypothesized that the nature of the mutagenic environment in which SCC develops directly affects the incidence of immunohistochemically detectable p53-positive cells. Copyright (C) 1995 by W.B. Saunders Company
引用
收藏
页码:531 / 533
页数:3
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