LIMITED SEQUENCE VARIATION IN HUMAN T-LYMPHOTROPIC VIRUS TYPE-1 ISOLATES FROM NORTH-AMERICAN AND AFRICAN PATIENTS

被引:115
作者
PAINE, E
GARCIA, J
PHILPOTT, TC
SHAW, G
RATNER, L
机构
[1] WASHINGTON UNIV, DEPT MED, ST LOUIS, MO 63110 USA
[2] WASHINGTON UNIV, DEPT MOLEC MICROBIOL, ST LOUIS, MO 63110 USA
[3] UNIV ALABAMA, DEPT MED, BIRMINGHAM, AL 35294 USA
[4] UNIV ALABAMA, DEPT BIOCHEM, BIRMINGHAM, AL 35294 USA
关键词
D O I
10.1016/0042-6822(91)90654-T
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Nucleotide sequences were determined from the env genes of three HTLV-I clones derived from two North American patients and one African patient with adult T-cell leukemia/lymphoma (ATLL region, between env and the 3′LTR, were determined from one of these isolates. These data were compared to sequences derived from HTLV-I isolates of two Japanese ATLL patients, a Japanese patient with HTLV-I-associated myelopathy or tropical spastic paraparesis (HAM/TSP) and a Caribbean ATLL patient. Nucleotide sequence variation was found to be <6% in coding and noncoding regions. Predicted amino acid sequences varied between 0.6 and 1.8% in the envelope, 0-3.7% in rex, 0.8-2.5% in the tax gene product, and 3-14.0% in the pX-I open reading frame. Comparisons of the predicted amino acid sequences of the surface envelope protein (SU-gp46) suggest that the variation between isolates of different geographical origins is greater than that between isolates obtained from the same region of the world. © 1991.
引用
收藏
页码:111 / 123
页数:13
相关论文
共 65 条
  • [11] ENVELOPE GENE SEQUENCE OF HTLV-1 ISOLATE MT-2 AND ITS COMPARISON WITH OTHER HTLV-1 ISOLATES
    GRAY, GS
    WHITE, M
    BARTMAN, T
    MANN, D
    [J]. VIROLOGY, 1990, 177 (01) : 391 - 395
  • [12] COMPARATIVE-ANALYSIS OF THE HTLV-I REX AND HIV-1 REV TRANS-REGULATORY PROTEINS AND THEIR RNA RESPONSE ELEMENTS
    HANLY, SM
    RIMSKY, LT
    MALIM, MH
    KIM, JH
    HAUBER, J
    DODON, MD
    LE, SY
    MAIZEL, JV
    CULLEN, BR
    GREENE, WC
    [J]. GENES & DEVELOPMENT, 1989, 3 (10) : 1534 - 1544
  • [13] ANALYSIS OF THE FUNCTION OF VIRAL PROTEIN X(VPX) OF HIV-2
    HU, W
    VANDERHEYDEN, N
    RATNER, L
    [J]. VIROLOGY, 1989, 173 (02) : 624 - 630
  • [14] DNA BLOTTING ANALYSIS OF HUMAN RETROVIRUSES IN CEREBROSPINAL-FLUID OF SPASTIC PARAPARESIS PATIENTS - THE VIRUSES ARE IDENTICAL TO HUMAN T-CELL LEUKEMIA-VIRUS TYPE-1 (HTLV-1)
    IMAMURA, J
    TSUJIMOTO, A
    OHTA, Y
    HIROSE, S
    SHIMOTOHNO, K
    MIWA, M
    MIYOSHI, I
    [J]. INTERNATIONAL JOURNAL OF CANCER, 1988, 42 (02) : 221 - 224
  • [15] SEQUENCES RESPONSIBLE FOR ERYTHROID AND LYMPHOID LEUKEMIA IN THE LONG TERMINAL REPEATS OF FRIEND-MINK CELL FOCUS-FORMING AND MOLONEY MURINE LEUKEMIA VIRUSES
    ISHIMOTO, A
    TAKIMOTO, M
    ADACHI, A
    KAKUYAMA, M
    KATO, S
    KAKIMI, K
    FUKUOKA, K
    OGIU, T
    MATSUYAMA, M
    [J]. JOURNAL OF VIROLOGY, 1987, 61 (06) : 1861 - 1866
  • [16] A NEW SUBTYPE OF HUMAN T-CELL LEUKEMIA-VIRUS (HTLV-II) ASSOCIATED WITH A T-CELL VARIANT OF HAIRY-CELL LEUKEMIA
    KALYANARAMAN, VS
    SARNGADHARAN, MG
    ROBERTGUROFF, M
    MIYOSHI, I
    BLAYNEY, D
    GOLDE, D
    GALLO, RC
    [J]. SCIENCE, 1982, 218 (4572) : 571 - 573
  • [17] KANNAGI M, 1984, J IMMUNOL, V133, P1037
  • [18] KAWANO F, 1985, CANCER-AM CANCER SOC, V55, P851, DOI 10.1002/1097-0142(19850215)55:4<851::AID-CNCR2820550424>3.0.CO
  • [19] 2-J
  • [20] LACK OF A NEGATIVE INFLUENCE ON VIRAL GROWTH BY THE NEF GENE OF HUMAN IMMUNODEFICIENCY VIRUS TYPE-1
    KIM, SY
    IKEUCHI, KJ
    BYRN, R
    GROOPMAN, J
    BALTIMORE, D
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (23) : 9544 - 9548