学术探索
学术期刊
新闻热点
数据分析
智能评审

CHEMICAL OXIDATION OF 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP) AND ITS INVIVO METABOLISM IN RAT-BRAIN AND LIVER

被引：20
作者：
ARORA, PK
RIACHI, NJ
HARIK, SI
SAYRE, LM
机构：
[1] CASE WESTERN RESERVE UNIV,DEPT CHEM,CLEVELAND,OH 44106
[2] CASE WESTERN RESERVE UNIV,DEPT NEUROL,CLEVELAND,OH 44106
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1988年 / 152卷 / 03期
关键词：
D O I：
10.1016/S0006-291X(88)80432-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：1339 / 1347
页数：9
相关论文
共 26 条
  • [1] METABOLISM OF 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP) IN MOUSE-LIVER PREPARATIONS
    BAKER, JK
    BORNE, RF
    DAVIS, WM
    WATERS, IW
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 125 (02) : 484 - 490
  • [2] ENZYME ALDEHYDE OXIDASE IS AN IMINIUM OXIDASE - REACTION WITH NICOTINE DELTA-1'(5')IMINIUM ION
    BRANDANGE, S
    LINDBLOM, L
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1979, 91 (03) : 991 - 996
  • [3] CASHMAN JR, 1986, MOL PHARMACOL, V29, P163
  • [4] CHIBA K, 1985, DRUG METAB DISPOS, V13, P342
  • [5] MODEL STUDY ON THE BIOREDUCTION OF PARAQUAT, MPP+, AND ANALOGS - EVIDENCE AGAINST A REDOX CYCLING MECHANISM IN MPTP NEUROTOXICITY
    FRANK, DM
    ARORA, PK
    BLUMER, JL
    SAYRE, LM
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 147 (03) : 1095 - 1104
  • [6] METABOLISM OF THE NEUROTOXIN IN MPTP BY HUMAN-LIVER MONOAMINE OXIDASE-B
    FRITZ, RR
    ABELL, CW
    PATEL, NT
    GESSNER, W
    BROSSI, A
    [J]. FEBS LETTERS, 1985, 186 (02): : 224 - 228
  • [7] CONVERSION OF 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP) AND ITS 5-METHYL ANALOG INTO PYRIDINIUM SALTS
    GESSNER, W
    BROSSI, A
    SHEN, RS
    FRITZ, RR
    ABELL, CW
    [J]. HELVETICA CHIMICA ACTA, 1984, 67 (08) : 2037 - 2042
  • [8] PREPARATION AND REACTIONS OF PYRIDONES - STERIC AND ELECTRONIC EFFECTS ON CYCLO-ADDITIONS WITH 2(1H)-PYRIDONES
    GISBY, GP
    ROYALL, SE
    SAMMES, PG
    [J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1982, (01): : 169 - 173
  • [9] HARIK SI, 1987, J PHARMACOL EXP THER, V241, P669
  • [10] INHIBITION OF MITOCHONDRIAL RESPIRATION BY ANALOGS OF 4-PHENYLPYRIDINE AND 1-METHYL-4-PHENYLPYRIDINIUM CATION (MPP+), THE NEUROTOXIC METABOLITE OF MPTP
    HOPPEL, CL
    GREENBLATT, D
    KWOK, HC
    ARORA, PK
    SINGH, MP
    SAYRE, LM
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 148 (02) : 684 - 693
123