INVESTIGATING THE NONCOVALENT INTERACTION OF CYTIDYLIC ACIDS, WITH RIBONUCLEASE-A BY ELECTROSPRAY MASS-SPECTROMETRY

被引:18
作者
CAMILLERI, P
HASKINS, NJ
机构
[1] SmithKline Beecham, Welwyn, Hertfordshire
关键词
D O I
10.1002/rcm.1290070709
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Electrospray mass spectrometry has been applied to probe the binding of 2'-CMP,3'-CMP and 2'3'-CMP to RNaseA. Results show that, in the presence of excess amounts of these molecules, binding also appears to occur at a secondary site on the enzyme.
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页码:603 / 604
页数:2
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