PHARMACOKINETICS OF 3'-FLUORO-3'-DEOXYTHYMIDINE AND 3'-DEOXY-2',3'-DIDEHYDROTHYMIDINE IN RATS

被引：16

作者：

BOUDINOT, FD

SMITH, SG

FUNDERBURG, ED

SCHINAZI, RF

机构：

[1] EMORY UNIV,SCH MED,DEPT PEDIAT,BIOCHEM PHARMACOL LAB,ATLANTA,GA 30322

[2] VET AFFAIRS MED CTR,DECATUR,GA 30033

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1991年 / 35卷 / 04期

关键词：

D O I：

10.1128/AAC.35.4.747

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Concentrations of 3'-fluoro-3'-deoxythymidine (FDT) and 3'-deoxy-2',3'-didehydrothymidine (D4T) in plasma declined in a biexponential fashion. Total clearance of D4T (1.75 +/- 0.22 liters/h/kg; mean +/- standard deviation) was significantly greater than that of FDT (1.19 +/- 0.19 liters/h/kg) owing to greater renal and nonrenal clearances of the former. Steady-state volumes of distribution of FDT (1.20 +/- 0.12 liters/kg) and D4T (1.07 +/- 0.15 liters/kg) were similar.

引用

页码：747 / 749

页数：3

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