EFFECT OF SPERMINE ON MITOCHONDRIAL GLUTATHIONE RELEASE

被引：47

作者：

RIGOBELLO, MP ^{[1
]}

TONINELLO, A ^{[1
]}

SILIPRANDI, D ^{[1
]}

BINDOLI, A ^{[1
]}

机构：

[1] UNIV PADUA, DIPARTIMENTO CHIM BIOL, I-35100 PADUA, ITALY

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 194卷 / 03期

关键词：

D O I：

10.1006/bbrc.1993.1961

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Spermine prevents glutathione release induced in rat liver mitochondria by the combined addition of Ca2+ and phosphate. Spermine also inhibitsd mitochondrial swelling, membrane potential decrease, oxygen uptake and [14C] sucrose entry stimulated by the above reported agent. Mitochondrial swelling is completely prevented by 25 μM spermine while higher concentrations (100 μM) are required for the full inhibition of glutathione release. Therefore, polyamines decrease the mitochondrial inner membrane permeability and, by preventing mitochondrial glutathione loss, also act as protective agents against oxidative stress. © 1993 Academic Press, Inc.

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页码：1276 / 1281

页数：6

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