Rat Brain Capillary Endothelial Cells Express Functional PDGF B-Type Receptors

被引:156
作者
Smits, Anja [1 ,2 ]
Hermansson, Monica [1 ,2 ]
Nister, Monica [3 ]
Karnushina, Irina [4 ]
Heldin, Carl-Henrik [1 ,2 ]
Westermark, Benct [3 ]
Funa, Keiko [1 ,2 ]
机构
[1] Ludwig Inst Canc Res, Biomed Ctr, Box 595, S-75123 Uppsala, Sweden
[2] Univ Hosp, S-75123 Uppsala, Sweden
[3] Univ Hosp, Dept Pathol, Uppsala, Sweden
[4] Karolinska Inst, Dept Med Chem, Stockholm, Sweden
关键词
Platelet-derived growth factor; receptor; capillaries; endothelial cells;
D O I
10.3109/08977198909069076
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Immunohistochemical staining revealed the presence of platelet-derived growth factor (PDGF) 8-type receptors on capillaries of normal rat brain. Furthermore, capillary endothelial cells isolated from rat brain and grown in tissue culture bound [I-125]PDGF-BBb ut not [I-125]PDGF-AA,suggesting that they expressed B-type, but not A-type, PDGF receptors. PDGF-BB and PDGF-AB, but not PDGF-AA, also stimulated incorporation of [H-3]thymidine into these cells. Thus, rat brain capillary endothelial cells have functional B-type receptors, and thereby differ from endothelial cells derived from large blood vessels, that do not express PDGF receptors. Our data suggest a possible role for PDGF-BB as an angiogenic factor.
引用
收藏
页码:1 / 8
页数:8
相关论文
共 32 条
  • [11] HART IK, 1989, DEVELOPMENT, V105, P595
  • [12] SPECIFIC RECEPTORS FOR PLATELET-DERIVED GROWTH-FACTOR ON CELLS DERIVED FROM CONNECTIVE-TISSUE AND GLIA
    HELDIN, CH
    WESTERMARK, B
    WASTESON, A
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (06): : 3664 - 3668
  • [13] BINDING OF DIFFERENT DIMERIC FORMS OF PDGF TO HUMAN-FIBROBLASTS - EVIDENCE FOR 2 SEPARATE RECEPTOR TYPES
    HELDIN, CH
    BACKSTROM, G
    OSTMAN, A
    HAMMACHER, A
    RONNSTRAND, L
    RUBIN, K
    NISTER, M
    WESTERMARK, B
    [J]. EMBO JOURNAL, 1988, 7 (05) : 1387 - 1393
  • [14] PLATELET-DERIVED GROWTH-FACTOR - 3 ISOFORMS AND 2 RECEPTOR TYPES
    HELDIN, CH
    WESTERMARK, B
    [J]. TRENDS IN GENETICS, 1989, 5 (04) : 108 - 111
  • [15] A HUMAN OSTEOSARCOMA CELL-LINE SECRETES A GROWTH-FACTOR STRUCTURALLY RELATED TO A HOMODIMER OF PDGF A-CHAINS
    HELDIN, CH
    JOHNSSON, A
    WENNERGREN, S
    WERNSTEDT, C
    BETSHOLTZ, C
    WESTERMARK, B
    [J]. NATURE, 1986, 319 (6053) : 511 - 514
  • [16] ABERRANT EXPRESSION OF RECEPTORS FOR PLATELET-DERIVED GROWTH-FACTOR IN AN ANAPLASTIC THYROID-CARCINOMA CELL-LINE
    HELDIN, NE
    GUSTAVSSON, B
    CLAESSONWELSH, L
    HAMMACHER, A
    MARK, J
    HELDIN, CH
    WESTERMARK, B
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (23) : 9302 - 9306
  • [17] ENDOTHELIAL-CELL HYPERPLASIA IN HUMAN GLIOBLASTOMA - COEXPRESSION OF MESSENGER-RNA FOR PLATELET-DERIVED GROWTH-FACTOR (PDGF) B-CHAIN AND PDGF RECEPTOR SUGGESTS AUTOCRINE GROWTH-STIMULATION
    HERMANSSON, M
    NISTER, M
    BETSHOLTZ, C
    HELDIN, CH
    WESTERMARK, B
    FUNA, K
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (20) : 7748 - 7752
  • [18] JOO F, 1973, CYTOBIOS, V8, P41
  • [19] HETEROGENEITY IN ENDOTHELIAL-CELLS FROM LARGE VESSELS AND MICROVESSELS
    KUMAR, S
    WEST, DC
    AGER, A
    [J]. DIFFERENTIATION, 1987, 36 (01) : 57 - 70
  • [20] GRIFFONIA-SIMPLICIFOLIA LECTINS BIND SPECIFICALLY TO ENDOTHELIAL-CELLS AND SOME EPITHELIAL-CELLS IN MOUSE-TISSUES
    LAITINEN, L
    [J]. HISTOCHEMICAL JOURNAL, 1987, 19 (04): : 225 - 234