Rat Brain Capillary Endothelial Cells Express Functional PDGF B-Type Receptors

被引:156
作者
Smits, Anja [1 ,2 ]
Hermansson, Monica [1 ,2 ]
Nister, Monica [3 ]
Karnushina, Irina [4 ]
Heldin, Carl-Henrik [1 ,2 ]
Westermark, Benct [3 ]
Funa, Keiko [1 ,2 ]
机构
[1] Ludwig Inst Canc Res, Biomed Ctr, Box 595, S-75123 Uppsala, Sweden
[2] Univ Hosp, S-75123 Uppsala, Sweden
[3] Univ Hosp, Dept Pathol, Uppsala, Sweden
[4] Karolinska Inst, Dept Med Chem, Stockholm, Sweden
关键词
Platelet-derived growth factor; receptor; capillaries; endothelial cells;
D O I
10.3109/08977198909069076
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Immunohistochemical staining revealed the presence of platelet-derived growth factor (PDGF) 8-type receptors on capillaries of normal rat brain. Furthermore, capillary endothelial cells isolated from rat brain and grown in tissue culture bound [I-125]PDGF-BBb ut not [I-125]PDGF-AA,suggesting that they expressed B-type, but not A-type, PDGF receptors. PDGF-BB and PDGF-AB, but not PDGF-AA, also stimulated incorporation of [H-3]thymidine into these cells. Thus, rat brain capillary endothelial cells have functional B-type receptors, and thereby differ from endothelial cells derived from large blood vessels, that do not express PDGF receptors. Our data suggest a possible role for PDGF-BB as an angiogenic factor.
引用
收藏
页码:1 / 8
页数:8
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