Rat Brain Capillary Endothelial Cells Express Functional PDGF B-Type Receptors

被引：156

作者：

Smits, Anja ^{[1
,2
]}

Hermansson, Monica ^{[1
,2
]}

Nister, Monica ^{[3
]}

Karnushina, Irina ^{[4
]}

Heldin, Carl-Henrik ^{[1
,2
]}

Westermark, Benct ^{[3
]}

Funa, Keiko ^{[1
,2
]}

机构：

[1] Ludwig Inst Canc Res, Biomed Ctr, Box 595, S-75123 Uppsala, Sweden

[2] Univ Hosp, S-75123 Uppsala, Sweden

[3] Univ Hosp, Dept Pathol, Uppsala, Sweden

[4] Karolinska Inst, Dept Med Chem, Stockholm, Sweden

来源：

GROWTH FACTORS | 1989年 / 2卷 / 01期

关键词：

Platelet-derived growth factor; receptor; capillaries; endothelial cells;

D O I：

10.3109/08977198909069076

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Immunohistochemical staining revealed the presence of platelet-derived growth factor (PDGF) 8-type receptors on capillaries of normal rat brain. Furthermore, capillary endothelial cells isolated from rat brain and grown in tissue culture bound [I-125]PDGF-BBb ut not [I-125]PDGF-AA,suggesting that they expressed B-type, but not A-type, PDGF receptors. PDGF-BB and PDGF-AB, but not PDGF-AA, also stimulated incorporation of [H-3]thymidine into these cells. Thus, rat brain capillary endothelial cells have functional B-type receptors, and thereby differ from endothelial cells derived from large blood vessels, that do not express PDGF receptors. Our data suggest a possible role for PDGF-BB as an angiogenic factor.

引用

页码：1 / 8

页数：8

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