A STEREOSELECTIVE SYNTHESIS OF TRISUBSTITUTED ALKENES .2. THE NICKEL-CATALYZED COUPLING OF GRIGNARD-REAGENTS WITH 6-ALKYL-3,4-DIHYDRO-2H-PYRANS AND ACYCLIC ENOL ETHERS

被引：8

作者：

ASHWORTH, PA ^{[1
]}

DIXON, NJ ^{[1
]}

KOCIENSKI, PJ ^{[1
]}

WADMAN, SN ^{[1
]}

机构：

[1] UNIV SOUTHAMPTON,DEPT CHEM,SOUTHAMPTON SO9 5NH,HANTS,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1992年 / 24期

关键词：

D O I：

10.1039/p19920003431

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Ni0-catalysed coupling of Grignard reagents devoid of beta-hydrogens with 6-alkyl-3,4-dihydro-2H-pyrans and acyclic enol ethers is highly stereoselective and gives trisubstituted alkenes with retention of configuration. The reaction was applied to syntheses of the aggregation pheromone of the square-necked grain beetle, a fragment of Premonensin B, and the polyketide fragment of Jaspamide.

引用

页码：3431 / 3438

页数：8

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