NEW BETA-CYCLODEXTRIN DERIVATIVES POSSESSING BIOLOGICALLY-ACTIVE SACCHARIDE ANTENNAE

被引：23

作者：

PARROTLOPEZ, H ^{[1
]}

LERAY, E ^{[1
]}

COLEMAN, AW ^{[1
]}

机构：

[1] UNIV PARIS, CTR PHARMACEUT,CYCLODEXTRINES AMPHIPHILES GRP, CNRS,ER45, F-92296 CHATENAY MALABRY, FRANCE

来源：

SUPRAMOLECULAR CHEMISTRY | 1993年 / 3卷 / 01期

关键词：

D O I：

10.1080/10610279308029836

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The synthesis of monosubstituted beta-cyclodextrin derivatives having the monosaccharides, beta-D-glucose, beta-D-galactose, alpha-D-mannose, beta-L and beta-D-fucose linked to the macrocycle vis a C9 spacer chain is described. The approach is based on the highly efficient coupling of the NCS sugar derivatives to monomethyl nonanedicarboxylate to generate a stable amido linkage. The NMR studies show the saccharide antennae to be oriented into the environment and not towards the CD cavity.

引用

页码：37 / 42

页数：6

共 16 条

[1]

BODANSKY A, 1984, PRACTICE PEPTIDE SYN

[2]

CAMARASA MJ, 1984, SYNTHESIS-STUTTGART, P509

[3] A NOVEL METHOD FOR THE SPECIFIC GLYCOSYLATION OF PROTEINS [J].