CHANGES OF MECHANISMS AND PRODUCT DISTRIBUTIONS IN HYDROLYSIS OF BENZO[A]PYRENE-7,8-DIOL 9,10-EPOXIDE METABOLITES INDUCED BY CHANGES IN PH

被引：91

作者：

WHALEN, DL

MONTEMARANO, JA

THAKKER, DR

YAGI, H

JERINA, DM

机构：

[1] UNIV MARYLAND, DEPT CHEM, CHEM DYNAM LAB, CATONSVILLE, MD 21228 USA

[2] NIAMDD, CHEM LAB, BETHESDA, MD 20014 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1977年 / 99卷 / 16期

关键词：

D O I：

10.1021/ja00458a069

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

引用

页码：5522 / 5524

页数：3

共 19 条

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[17] SYNTHESIS OF (+/-)-7-BETA,8-ALPHA-DIHYDROXY-9-BETA,10-BETA-EPOXY-7,8,-9,10-TETRAHYDROBENZO[A]PYRENE, A POTENTIAL METABOLITE OF CARCINOGEN BENZO[A]PYRENE WITH STEREOCHEMISTRY RELATED TO ANTILEUKEMIC TRIPTOLIDES [J].

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[18] SYNTHESIS AND REACTIONS OF HIGHLY MUTAGENIC 7,8-DIOL 9,10-EPOXIDES OF CARCINOGEN BENZO[A]PYRENE [J].

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[19] ENZYMATIC CONVERSION OF BENZO[A]PYRENE LEADING PREDOMINANTLY TO DIOL-EPOXIDE R-7,T-8-DIHYDROXY-T-9,10-OXY-7,8,9,10-TETRAHYDROBENZO[A]PYRENE THROUGH A SINGLE ENANTIOMER OF R-7,T-8-DIHYDROXY-7,8-DIHYDROBENZO[A]PYRENE [J].

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