CYTOKINE-BINDING PROTEINS - STIMULATING ANTAGONISTS

被引:90
作者
KLEIN, B [1 ]
BRAILLY, H [1 ]
机构
[1] IMMUNOTECH SA,F-13276 MARSEILLE 09,FRANCE
来源
IMMUNOLOGY TODAY | 1995年 / 16卷 / 05期
关键词
D O I
10.1016/0167-5699(95)80161-8
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Cytokine-binding proteins (CBPs) block the ability of cytokines to interact with their receptors. These agents can potentially provide a means of treating pathological conditions that have a significant cytokine involvement. However, a major drawback of such approaches relates to the fact that CBPs stabilize the cytokine in the form of a cytokine-CBP complex in vivo. Here, Bernard Klein and Herve Brailly discuss the possibility that CBPs behave either as agonists or antagonists according to their pharmacokinetic characteristics in vivo, and suggest a mechanism by which stable complexes might be cleared from the system.
引用
收藏
页码:216 / 220
页数:5
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