FERTILE MALE-MICE WITH 3 SEX-CHROMOSOMES - EVIDENCE THAT INFERTILITY IN XYY MALE-MICE IS AN EFFECT OF 2 Y-CHROMOSOMES

被引：33

作者：

HUNT, PA

EICHER, EM

机构：

[1] The Jackson Laboratory, Bar Harbor, 04609, ME

来源：

CHROMOSOMA | 1991年 / 100卷 / 05期

关键词：

D O I：

10.1007/BF00360527

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the mouse XYY males are sterile, presumably because pairing abnormalities resulting from the presence of three sex chromosomes lead to meiotic breakdown. We have produced male mice, designated XYY*X, that have three sex chromosome pairing regions but only one intact Y chromosome. Unexpectedly XYY*X males are fertile, although they are no more efficient in sex chromosome pairing than previously reported XYY males. We conclude that the sterility of XYY males is caused by a combination of the deleterious effect of two Y chromosomes, presumably acting prior to meiosis, and pairing abnormalities resulting in significant meiotic disruption.

引用

页码：293 / 299

页数：7

共 23 条

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