PROTEIN ENGINEERING

被引：19

作者：

BRYAN, PN

机构：

[1] Genex Corp, Gaithersburg, MD, USA, Genex Corp, Gaithersburg, MD, USA

来源：

BIOTECHNOLOGY ADVANCES | 1987年 / 5卷 / 02期

关键词：

ENZYMES - GENETIC ENGINEERING;

D O I：

10.1016/0734-9750(87)90319-3

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The techniques of protein engineering are proving to be a revolutionary experimental tool for understanding protein structure-function relationships. Even at this early stage, proteins of improved characteristics for specific industrial and therapeutic uses have already been produced. Tailoring enzymatic properties for non-physiological substrate conditions, altering pH optima, changing substrate specificity, and improving stability have already been demonstrated to be feasible. Nevertheless, the ability to make useful proteins which radically differ from a natural structure or designing altogether new structures exceeds present understanding.

引用

页码：221 / &

共 41 条

[11] HYDROGEN-BONDING AND BIOLOGICAL SPECIFICITY ANALYZED BY PROTEIN ENGINEERING [J].