AN EFFICIENT SYNTHESIS OF 9-[(1-HYDROXYMETHYL)-CYCLOBUT-1-ENE-3-YL] ADENINE AND 1-(ADENIN-9-YL)-3-METHYLIDENE-BUT-1-ENE-4-OL VIA REGIOSPECIFIC ADDITION OF PHENYL SELENENYL BROMIDE TO THE ALKENE PRECURSOR

被引：8

作者：

GHARBAOUI, T

LEGRAVEREND, M

BISAGNI, E

机构：

[1] Laboratoire de synthèse organique, associé au CNRS, Institut Curie-Biologie, 91405 Orsay

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 47期

关键词：

D O I：

10.1016/S0040-4039(00)60857-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Phenylselenenyl bromide permits the efficient synthesis, in two steps, under mild conditions and in good yield of the allylic bromide 8 from 6-chloro-9-(3-methylidene-1-cyclobutyl) purine 4. Depending on the temperature, 9-[(1-hydroxymethyl)-cyclobut-1-ene-3-yl] adenine 1 and 1-(adenin-9-yl)-3-methylidene-but-1-ene-4-ol 2 were then specifically obtained in two steps.

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页码：7141 / 7144

页数：4

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