The Impact of Radiation on the Tumor Microenvironment: Effect of Dose and Fractionation Schedules

被引：119

作者：

Arnold, Kimberly M. ^{[1
,2
]}

Flynn, Nicole J. ^{[1
,3
]}

Raben, Adam ^{[4
]}

Romak, Lindsay ^{[4
]}

Yu, Yan ^{[5
]}

Dicker, Adam P. ^{[5
]}

Mourtada, Firas ^{[4
,5
]}

Sims-Mourtada, Jennifer ^{[1
,2
,3
]}

机构：

[1] Christiana Care Hlth Syst, Helen H Graham Canc Ctr & Res Inst, Ctr Translat Canc Res, Newark, DE USA

[2] Univ Delaware, Dept Med Lab Sci, Newark, DE USA

[3] Univ Delaware, Dept Biol Sci, Newark, DE USA

[4] Christiana Care Hlth Syst, Helen F Graham Canc Ctr & Res Inst, Dept Radiat Oncol, 4701 Ogletown Stanton Rd,Ste 1152, Newark, DE 19713 USA

[5] Thomas Jefferson Univ, Sidney Kimmel Med Coll & Canc Ctr, Dept Radiat Oncol, Philadelphia, PA 19107 USA

来源：

CANCER GROWTH AND METASTASIS | 2018年 / 11卷

关键词：

Radiation; tumor microenvironment; stroma; tumor immunity;

D O I：

10.1177/1179064418761639

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

In addition to inducing lethal DNA damage in tumor and stromal cells, radiation can alter the interactions of tumor cells with their microenvironment. Recent technological advances in planning and delivery of external beam radiotherapy have allowed delivery of larger doses per fraction (hypofractionation) while minimizing dose to normal tissues with higher precision. The effects of radiation on the tumor microenvironment vary with dose and fractionation schedule. In this review, we summarize the effects of conventional and hypofractionated radiation regimens on the immune system and tumor stroma. We discuss how these interactions may provide therapeutic benefit in combination with targeted therapies. Understanding the differential effects of radiation dose and fractionation can have implications for choice of combination therapies.

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页数：17

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