STEREOCONTROLLED ADDITION OF CHIRAL, NONRACEMIC AMIDE HOMOENOLATES TO T-BOC-(S)-PHENYLALANINAL

被引：23

作者：

ARMSTRONG, JD

HARTNER, FW

DECAMP, AE

VOLANTE, RP

SHINKAI, I

机构：

[1] Department of Process Research Merck Research Laboratories, Rahway, NJ 07065-0900

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 44期

关键词：

D O I：

10.1016/S0040-4039(00)60995-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of chiral indanolamide homoenolates 4a and 4c with t-Boc-(S)-phenylalaninal 3 exclusively gave the non-chelation product in contrast to the propionate ester homoenolate 7c, 1a which gives predominantly the chelation controlled product. However, the reaction of simple achiral amide homoenolates 7a and 7b with 3 was nonselective.

引用

页码：6599 / 6602

页数：4

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