CAP-BINDING COMPLEXES AND CELLULAR GROWTH-CONTROL

被引：30

作者：

MADER, S

SONENBERG, N

机构：

[1] MCGILL UNIV,DEPT BIOCHEM,MONTREAL,PQ H3G 1Y6,CANADA

[2] MCGILL UNIV,MCGILL CANC CTR,MONTREAL,PQ H3G 1Y6,CANADA

来源：

BIOCHIMIE | 1995年 / 77卷 / 1-2期

关键词：

CAP BINDING COMPLEXES; TRANSLATION INITIATION; TRANSFORMATION; EIF-4F;

D O I：

10.1016/0300-9084(96)88102-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cap-binding complex eIF-4F plays a major role in the control of translation initiation, and overexpression of its limiting subunit, eIF-4E, leads to the deregulation of cellular growth. The recent cloning of eIF-4E binding proteins (4E-BPs) has uncovered a previously unsuspected pathway for the regulation of eIF-4E activity, through sequestration of eIF-4E as a complex with 4E-BPs.

引用

页码：40 / 44

页数：5

共 77 条

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