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CAP-BINDING COMPLEXES AND CELLULAR GROWTH-CONTROL

被引：30
作者：
MADER, S
SONENBERG, N
机构：
[1] MCGILL UNIV,DEPT BIOCHEM,MONTREAL,PQ H3G 1Y6,CANADA
[2] MCGILL UNIV,MCGILL CANC CTR,MONTREAL,PQ H3G 1Y6,CANADA
来源：
BIOCHIMIE | 1995年 / 77卷 / 1-2期
关键词：
CAP BINDING COMPLEXES; TRANSLATION INITIATION; TRANSFORMATION; EIF-4F;
D O I：
10.1016/0300-9084(96)88102-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The cap-binding complex eIF-4F plays a major role in the control of translation initiation, and overexpression of its limiting subunit, eIF-4E, leads to the deregulation of cellular growth. The recent cloning of eIF-4E binding proteins (4E-BPs) has uncovered a previously unsuspected pathway for the regulation of eIF-4E activity, through sequestration of eIF-4E as a complex with 4E-BPs.
引用
收藏
页码：40 / 44
页数：5
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