Reasons for cancer metastasis: A holistic perspective (Review)

被引：19

作者：

Wang, Rui-An ^{[1
,2
,3
]}

Lu, You-Yong ^{[4
]}

Fan, Dai-Ming ^{[1
,5
]}

机构：

[1] Fourth Mil Med Univ, State Key Lab Canc Biol, Xian 710032, Shaanxi, Peoples R China

[2] Fourth Mil Med Univ, Xijing Hosp, Dept Pathol, Xian 710032, Shaanxi, Peoples R China

[3] Fourth Mil Med Univ, Dept Pathol & Pathophysiol, 17 West Changle Rd, Xian 710032, Shaanxi, Peoples R China

[4] Peking Univ Canc Hosp & Inst, Lab Mol Oncol, Minist Educ, Key Lab Carcinogenesis & Translat Res, Beijing 100142, Peoples R China

[5] Fourth Mil Med Univ, Xijing Hosp Digest Dis, Xian 710032, Shaanxi, Peoples R China

来源：

MOLECULAR AND CLINICAL ONCOLOGY | 2015年 / 3卷 / 06期

关键词：

cancer; metastasis; necrosis; apoptosis; hypoxia; glycolysis; Warburg effect; radiotherapy; chemotherapy;

D O I：

10.3892/mco.2015.623

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Over several years, scientists investigating cancer have focused their efforts on elucidating the mechanisms underlying cancer metastasis, with the aim of finding a way to inhibit this process. These mechanisms, however, only explain the process of cancer metastasis, but do not explain why cancer would metastasize in the first place. Cancer metastasizes due to several factors, namely attack by the immune system, lack of oxygen and necessary nutrients, large amounts of lactic acid produced by glycolysis and increased cell death. Therefore, the majority of the presently available treatments for cancer also bear the potential to induce metastasis. Thus, it is crucial in medical practice to minimize the risk of cancer metastasis during a time when there are no effective means to inhibit this process.

引用

页码：1199 / 1202

页数：4

共 47 条

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