BIOSYNTHESIS OF 19-HYDROXY-PROSTAGLANDIN A1

被引：90

作者：

ISRAELSSON, U

HAMBERG, M

SAMUELSSON, B

机构：

[1] Institutionen für Medicinsk Kemi, Kungliga Veterinärhögskolan, Stockholm

来源：

EUROPEAN JOURNAL OF BIOCHEMISTRY | 1969年 / 11卷 / 02期

关键词：

D O I：

10.1111/j.1432-1033.1969.tb00785.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Prostaglandin A1, prostaglandin E1 and 11α‐hydroxy‐9,15‐diketoprostanoic acid have been incubated with guinea pig liver microsomes plus boiled high speed supernatant supplemented with NADPH. Prostaglandin A1 was converted in 10–18% yield into 19‐hydroxy‐prostaglandin A1 (35%) and 20‐hydroxy‐prostaglandin A1 (65%). Prostaglandin E1 gave a very small yield (less than 3%) of a hydroxylated derivative, and 11α‐hydroxy‐9,15‐diketoprostanoic acid was not hydroxylated at all. In the latter case, however, a reduction of the side chain keto group took place, affording 11α,15‐dihydroxy‐9‐ketoprostanoic acid. Copyright © 1969, Wiley Blackwell. All rights reserved

引用

页码：390 / +

页数：1

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