A NOVEL MONOCYCLIC DIENEDIYNE SYSTEM - SYNTHESIS AND MODE OF AROMATIZATION

被引：16

作者：

TOSHIMA, K

YANAGAWA, K

OHTA, K

KANO, T

NAKATA, M

机构：

[1] Department of Applied Chemistry, Keio University, Kohoku-ku, Yokohama, 223

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 10期

关键词：

D O I：

10.1016/S0040-4039(00)76761-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The novel monocyclic dienediyne 2, which is a simplified analogue of the neocarzinostatin chromophore (1), was synthesized from D-xylitol via conversion of the keto-aldehyde 13 into the highly strained 10-membered ring compound 14 by a simple intramolecular aldol condensation as the key step. The mode of cycloaromatization of 2 by a thiol addition, reminiscent of the chemistry of 1, was also demonstrated.

引用

页码：1573 / 1576

页数：4

共 35 条

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