SEQUENCE SIMILARITY BETWEEN MACROLIDE-RESISTANCE DETERMINANTS AND ATP-BINDING TRANSPORT PROTEINS

被引：70

作者：

SCHONER, B

GEISTLICH, M

ROSTECK, P

RAO, RN

SENO, E

REYNOLDS, P

COX, K

BURGETT, S

HERSHBERGER, C

机构：

[1] ELI LILLY & CO,LILLY RES LAB,LILLY CORP CTR,INDIANAPOLIS,IN 46285

[2] HARVARD UNIV,BIOL LABS,DEPT CELLULAR & DEV BIOL,CAMBRIDGE,MA 02138

来源：

GENE | 1992年 / 115卷 / 1-2期

关键词：

RECOMBINANT DNA; ANTIBIOTIC EXCRETION; EFFLUX; STREPTOMYCES;

D O I：

10.1016/0378-1119(92)90545-Z

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The three macrolide-resistance-encoding genes, tlrC from Streptomyces fradiae, srmB from Streptomyces ambofaciens, and carA from Streptomyces thermotolerans, encode proteins that possess significant sequence similarity to ATP-dependent transport proteins. The N-terminal and C-terminal halves of these proteins are very similar to each other and contain highly conserved regions that resemble ATP-binding domains typically present within the superfamily of ATP-dependent transport proteins. These observations suggest that the mechanism by which these genes confer resistance to macrolides is due to export of the antibiotics, a process that is driven by energy derived from ATP hydrolysis.

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页码：93 / 96

页数：4

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