USE OF CYCLODEXTRINS IN CAPILLARY ELECTROPHORESIS FOR THE CHIRAL RESOLUTION OF SOME 2-ARYLPROPIONIC ACID NONSTEROIDAL ANTIINFLAMMATORY DRUGS

The enantiomeric separation of racemic compounds of some 2-arylpropionic acid non-steroidal anti-inflammatory drugs (profens), namely fenoprofen, ibuprofen, flurbiprofen, suprofen, ketoprofen and indoprofen, was performed by capillary zone electrophoresis. The separation was obtained by supporting the background electrolyte with derivatized beta-cyclodextrins. The type and concentration of cyclodextrin used and the background electrolyte composition (pH and amount of methanol) influenced the complexation and the chiral resolution. All the modified beta-cyclodextrins used (heptakis-2,6-di-O-methyl-beta-, heptakis-2,3,6-tri-O-methyl- and 6(A)-methylamino-beta-cyclodextrin) showed good complexing effects with the profens tested. Tri-O-methyl-beta-cyclodextrin proved to be the best stereoselective additive because it allowed the enantiomeric resolution of all the profens studied whereas the dimethylated and methylamino-beta-cyclodextrin were able to separate only some of them.