EVIDENCE THAT BINDING TO THE S-2-SUBSITE OF PAPAIN MAY BE COUPLED WITH CATALYTICALLY RELEVANT STRUCTURAL-CHANGE INVOLVING THE CYSTEINE-25-HISTIDINE-159 DIAD - KINETICS OF THE REACTION OF PAPAIN WITH A 2-PROTONIC-STATE REACTIVITY PROBE CONTAINING A HYDROPHOBIC SIDE-CHAIN

被引：21

作者：

BROCKLEHURST, K

MALTHOUSE, JPG

SHIPTON, M

机构：

来源：

BIOCHEMICAL JOURNAL | 1979年 / 183卷 / 02期

关键词：

D O I：

10.1042/bj1830223

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

[No abstract available]

引用

页码：223 / 231

页数：9

共 37 条

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[2] BAINES BS, 1978, BIOCHEM J, V173, P345, DOI 10.1042/bj1730345
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[4] INHIBITION OF PAPAIN BY N-ACYL-AMINOACETALDEHYDES AND N-ACYL-AMINOPROPANONES - EVIDENCE FOR HEMITHIOACETAL FORMATION BY A CROSS-SATURATION TECHNIQUE IN NMR-SPECTROSCOPY
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[6] IMPORTANCE OF CONFORMATION OF TETRAHEDRAL INTERMEDIATE FOR ALPHA-CHYMOTRYPSIN-CATALYZED HYDROLYSIS OF PEPTIDE SUBSTRATES
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[7] EQUILIBRIUM ASSUMPTION IS VALID FOR THE KINETIC TREATMENT OF MOST TIME-DEPENDENT PROTEIN-MODIFICATION REACTIONS
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[8] COVALENT CHROMATOGRAPHY - PREPARATION OF FULLY ACTIVE PAPAIN FROM DRIED PAPAYA-LATEX
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[9] PH-DEPENDENCE OF 2ND-ORDER RATE CONSTANTS OF ENZYME MODIFICATION MAY PROVIDE FREE-REACTANT PKA VALUES
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[10] MECHANISM OF REACTION OF PAPAIN WITH SUBSTRATE-DERIVED DIAZOMETHYL KETONES - IMPLICATIONS FOR DIFFERENCE IN SITE SPECIFICITY OF HALOMETHYL KETONES FOR SERINE PROTEINASES AND CYSTEINE PROTEINASES AND FOR STEREOELECTRONIC REQUIREMENTS IN PAPAIN CATALYTIC MECHANISM
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MALTHOUSE, JPG
[J]. BIOCHEMICAL JOURNAL, 1978, 175 (02) : 761 - 764

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