ANALGESIC, ANESTHETIC, AND RESPIRATORY EFFECTS OF THE COMPETITIVE N-METHYL-D-ASPARTATE (NMDA) ANTAGONIST CGS-19755 IN RHESUS-MONKEYS

被引：35

作者：

FRANCE, CP ^{[1
]}

WINGER, GD ^{[1
]}

WOODS, JH ^{[1
]}

机构：

[1] UNIV MICHIGAN,SCH MED,DEPT PSYCHOL,ANN ARBOR,MI 48104

来源：

BRAIN RESEARCH | 1990年 / 526卷 / 02期

关键词：

Analgesia; Anesthesia; CGS; 19755; Excitatory amino acid antagonist; Respiration; Rhesus monkey;

D O I：

10.1016/0006-8993(90)91247-E

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The competitive excitatory amino acid antagonist cis-4-phosphonomethyl-2-piperidine-carboxylic acid (CGS 19755) increased the latency for monkeys to remove their tails from warm water (analgesia); larger doses produced ataxia, loss of righting, salivation, and eliminated reactivity to stimulation (anasthesia). CGS 19755 decreased tidal volume and had little effect on frequency of respiration. Although longer lasting, the effects of CGS 19755 were similar to the effects of ketamine, suggesting these effects result from actions at the NMDA receptor complex. © 1990.

引用

页码：355 / 358

页数：4

共 10 条

[1]

BENNETT DA, 1989, J PHARMACOL EXP THER, V250, P454

[2] A TAIL WITHDRAWAL PROCEDURE FOR ASSESSING ANALGESIC ACTIVITY IN RHESUS-MONKEYS [J].