UNCONVENTIONAL NUCLEOTIDE ANALOGUES .3. 4-(N1-PYRIMIDYL)-2-AMINOBUTYRIC ACIDS

被引：18

作者：

NOLLET, AJH

PANDIT, UK

机构：

[1] Laboratory of Oiganic Chemistry, University of Amsterdam, Amsterdam

来源：

TETRAHEDRON | 1969年 / 25卷 / 24期

关键词：

D O I：

10.1016/S0040-4020(01)83106-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Alkylation of 4-ethoxy-2-hydroxypyrimidines (10a, b), via their anions, provides a convenient procedure for preparing N1-substituted derivatives. Reaction of 10a, b with t-butyl 4-bromo-2-benzyloxycarbamidobutyrate (17) gives good yields of the N1-alkylated products 18a, b. The latter have been converted to uracil- (20a), thymine- (20b) and cytosine- (21) substituted α-aminobutyric acids. © 1969.

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页码：5989 / &

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