ASYMMETRIC-SYNTHESIS OF THE AB-RING OF AKLAVINONE

被引：10

作者：

DAVIS, FA

KUMAR, A

机构：

[1] Department of Chemistry, Drexel University, Philadelphia

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 52期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0040-4039(91)80561-J

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A formal synthesis of the AB-ring of aklavinone 3 was achieved via the asymmetric synthesis of diol 8 prepared in three steps from tetralone 5. The crucial step involved the asymmetric hydroxylation of 5 in greater-than-or-equal-to 95% ee using (camphorylsulfonyl)oxaziridine derivative (+)-4b.

引用

页码：7671 / 7674

页数：4

共 22 条

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DAVIS, FA
CHEN, BC
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[3] A HIGHLY ENANTIOSELECTIVE SYNTHESIS OF (R)-(-)-2-ACETYL-5,8-DIMETHOXY-1,2,3,4-TETRAHYDRO-2-NAPHTHOL - A KEY INTERMEDIATE IN THE SYNTHESIS OF ANTHRACYCLINONES
DAVIS, FA
KUMAR, A
CHEN, BC
[J]. TETRAHEDRON LETTERS, 1991, 32 (07) : 867 - 870
[4] ENANTIOSELECTIVE SYNTHESIS OF TERTIARY ALPHA-HYDROXY CARBONYL-COMPOUNDS USING ((8,8-DICHLOROCAMPHORYL)SULFONYL)OXAZIRIDINE
DAVIS, FA
WEISMILLER, MC
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1990, 55 (12) : 3715 - 3717
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DAVIS, FA
SHEPPARD, AC
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DAVIS, FA
KUMAR, A
CHEN, BC
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1991, 56 (03) : 1143 - 1145
[7] DELNERO S, 1981, CHEM IND-LONDON, P810
[8] A SHORT SYNTHESIS OF 2 CHIRAL ANTHRACYCLINE AB SYNTHONS
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VISKI, P
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1991, 56 (17) : 5226 - 5229
[9] HORI S, 1977, GANN, V68, P685
[10] KROHN K, 1990, TETRAHEDRON, V46, P291

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