SYNTHESIS AND ANTIPLATELET EFFECTS OF OMEGA-AMINOALKOXYLXANTHONES

被引：9

作者：

LIN, CN

LIOU, SS

LAI, SC

LIN, HC

KO, FN

LIU, HW

TENG, CM

机构：

[1] KAOHSIUNG MED COLL,SCH TECHNOL MED SCI,KAOHSIUNG 807,TAIWAN

[2] KAOHSIUNG MED COLL,DEPT INTERNAL MED,KAOHSIUNG 807,TAIWAN

[3] NATL TAIWAN UNIV,COLL MED,INST PHARMACOL,TAIPEI 100,TAIWAN

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1995年 / 47卷 / 07期

关键词：

D O I：

10.1111/j.2042-7158.1995.tb06720.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A series of omega-aminoalkoxylxanthones were synthesized and tested in-vitro for their ability to inhibit aggregation of rabbit washed platelets and human platelet-rich plasma (PRP) induced by various inducers. Nine of these compounds showed more potent antiplatelet effects than natural norathyriol tetraacetate on collagen-induced aggregation. The various omega-aminoalkoxyl side chains of the synthesized compounds modified the antiplatelet effects. All the compounds tested in human PRP showed significant inhibition of secondary aggregation induced by adrenaline, suggesting that the antiplatelet effects of these compounds is mainly due to an inhibitory effect on thromboxane formation. These compounds at high concentration also cause vasorelaxing action in rat thoracic aorta.

引用

页码：588 / 594

页数：7

共 14 条

[1] XANTHONOLOL - A CALCIUM-CHANNEL AND BETA-ADRENOCEPTOR BLOCKER WITH VASODILATING PROPERTIES [J].