NEUROTROPHIC EFFECT OF EPIDERMAL GROWTH-FACTOR ON CULTURED BRAIN NEURONS ARE BLOCKED BY PROTEIN-KINASE INHIBITORS

被引：5

作者：

ABE, K

TAKAYANAGI, M

SAITO, H

机构：

[1] Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 1992年 / 59卷 / 02期

关键词：

EPIDERMAL GROWTH FACTOR; NEUROTROPHIC EFFECT; PROTEIN KINASE INHIBITORS;

D O I：

10.1254/jjp.59.259

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The influences of protein kinase inhibitors, K-252a and staurosporine, on the neurotrophic effects of epidermal growth factor (EGF) were investigated in dissociated cell cultures of the hippocampus and cerebellum of fetal rats. Addition of 1 ng/ml EGF enhanced the survival of cultured neurons of both brain regions. Both K-252a (10 - 200 nM) and staurosporine (1 - 100 nM) blocked the survival-promoting effects of EGF in a concentration-dependent manner. These results suggest that activation of protein kinase(s) is involved in the neurotrophic effects of EGF.

引用

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页码：259 / 261

页数：3

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