ENANTIOSELECTIVE SYNTHESES OF (S)-3-HYDROXYPYRROLIDIN-2-ONE AND (R)-3-HYDROXYPYRROLIDIN-2-ONE VIA LACTATE-DEHYDROGENASE CATALYZED REDUCTIONS OF 4-BENZYLOXYCARBONYLAMINO-2-OXOBUTANOIC ACID

被引：16

作者：

BENTLEY, JM

WADSWORTH, HJ

WILLIS, CL

机构：

[1] UNIV BRISTOL,SCH CHEM,BRISTOL BS8 1TS,AVON,ENGLAND

[2] SMITHKLINE BEECHAM PHARMACEUT,HARLOW CM19 5AD,ESSEX,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1995年 / 02期

关键词：

D O I：

10.1039/c39950000231

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first examples of the BS- and SE-lactate dehydrogenase catalysed reductions of an alpha-keto acid incorporating a nitrogen containing function in the side chain are described: (S)- and (R)-benzyloxycarbonylamino-2-hydroxybutanoic acids were prepared in good yield and excellent enantioselectivities and were converted to the (S)- and (R)-3-hydroxypyrrolidin-2-ones respectively.

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页码：231 / 232

页数：2

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