SUPERANTIGENS AND RETROVIRAL INFECTION - INSIGHTS FROM MOUSE MAMMARY-TUMOR VIRUS

被引：86

作者：

HELD, W

ACHAORBEA, H

MACDONALD, HR

WAANDERS, GA

机构：

[1] Ludwig Institute for Cancer Research, Lausanne Branch

来源：

IMMUNOLOGY TODAY | 1994年 / 15卷 / 04期

关键词：

D O I：

10.1016/0167-5699(94)90317-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Superantigens induce a vigorous immune response by stimulating T cell's that express particular T-cell receptor Vbeta chains. Mouse mammary tumor virus is a milk-transmitted retrovirus that encodes such a superantigen. Paradoxically, as discussed by Werner Held and colleagues, the strong superantigen-induced immune response permits the survival of the virus via T-cell dependent clonal expansion of infected B cells.

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页码：184 / 190

页数：7

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