SYNTHESIS OF DEOXYDINUCLEOSIDE PHOSPHATES CONTAINING 6-THIO-SUBSTITUTED PURINE NUCLEOBASES

被引：10

作者：

CLIVIO, P

FOURREY, JL

FAVRE, A

机构：

[1] CNRS,INST CHIM SUBST NAT,F-91198 GIF SUR YVET,FRANCE

[2] CNRS,INST JACQUES MONOD,PHOTOBIOL MOLEC LAB,F-75251 PARIS 05,FRANCE

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1993年 / 21期

关键词：

D O I：

10.1039/p19930002585

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient preparative method to obtain. by the hydrogen phosphonate approach in solution, dinucleoside phosphates containing either 2'-deoxy-6-thioinosine or 2'-deoxy-6-thioguanosine at their 3' end, as in compounds 6 and 7, is described. For this purpose appropriate 5'-OH-free sulfur-modified deoxynucleoside intermediates required for this synthesis have been defined, as exemplified with the case of 2'-deoxy-6-thioguanosine.

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页码：2585 / 2590

页数：6

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