SYNTHESIS OF DEOXYDINUCLEOSIDE PHOSPHATES CONTAINING 4-THIO SUBSTITUTED PYRIMIDINE NUCLEOBASES
被引:17
作者:
CLIVIO, P
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机构:CNRS,INST CHIM SUBST NAT,F-91198 GIF SUR YVETTE,FRANCE
CLIVIO, P
FOURREY, JL
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机构:CNRS,INST CHIM SUBST NAT,F-91198 GIF SUR YVETTE,FRANCE
FOURREY, JL
GASCHE, J
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机构:CNRS,INST CHIM SUBST NAT,F-91198 GIF SUR YVETTE,FRANCE
GASCHE, J
FAVRE, A
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机构:CNRS,INST CHIM SUBST NAT,F-91198 GIF SUR YVETTE,FRANCE
FAVRE, A
机构:
[1] CNRS,INST CHIM SUBST NAT,F-91198 GIF SUR YVETTE,FRANCE
[2] CNRS,INST JACQUES MONOD,PHOTOBIOL MOLEC LAB,F-75251 PARIS 05,FRANCE
来源:
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
|
1992年
/
18期
关键词:
D O I:
10.1039/p19920002383
中图分类号:
O62 [有机化学];
学科分类号:
070303 ;
081704 ;
摘要:
The preparations, by the hydrogenphosphonate approach in solution, of the five pyrimidine deoxydinucleoside monophosphates 14a, 14b, 16a, 16b and 17 containing a 4-thiosubstituted pyrimidine nucleobase at either their 3'- or 5'-end are described. These syntheses were conveniently accomplished using 4-thionucleoside derivatives having their sulfur function protected by S-pivaloyloxymethylation. The behaviour of unprotected 4-thionucleoside derivatives was also investigated and they were shown to give comparable overall yields.