SYNTHESIS OF DEOXYDINUCLEOSIDE PHOSPHATES CONTAINING 4-THIO SUBSTITUTED PYRIMIDINE NUCLEOBASES

被引：17

作者：

CLIVIO, P

FOURREY, JL

GASCHE, J

FAVRE, A

机构：

[1] CNRS,INST CHIM SUBST NAT,F-91198 GIF SUR YVETTE,FRANCE

[2] CNRS,INST JACQUES MONOD,PHOTOBIOL MOLEC LAB,F-75251 PARIS 05,FRANCE

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1992年 / 18期

关键词：

D O I：

10.1039/p19920002383

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The preparations, by the hydrogenphosphonate approach in solution, of the five pyrimidine deoxydinucleoside monophosphates 14a, 14b, 16a, 16b and 17 containing a 4-thiosubstituted pyrimidine nucleobase at either their 3'- or 5'-end are described. These syntheses were conveniently accomplished using 4-thionucleoside derivatives having their sulfur function protected by S-pivaloyloxymethylation. The behaviour of unprotected 4-thionucleoside derivatives was also investigated and they were shown to give comparable overall yields.

引用

页码：2383 / 2388

页数：6

共 26 条

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