IS LEAD TOXICOSIS A REFLECTION OF ALTERED FATTY-ACID COMPOSITION OF MEMBRANES

被引:78
作者
DONALDSON, WE [1 ]
KNOWLES, SO [1 ]
机构
[1] N CAROLINA STATE UNIV, DEPT TOXICOL, RALEIGH, NC 27695 USA
来源
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY | 1993年 / 104卷 / 03期
关键词
D O I
10.1016/0742-8413(93)90003-4
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
1. The premise of this review is that many of the biological effects of Pb are reflections of tissue peroxidation. 2. Enhanced tissue levels of arachidonic acid in Pb toxicosis appear to be involved in the peroxidative changes. 3. The altered arachidonate metabolism may be related to changes in membrane structure and function. 4. The induction of enhanced glutathione levels in animal tissues by Pb may afford protection from peroxidative damage.
引用
收藏
页码:377 / 379
页数:3
相关论文
共 41 条
[1]   TRIETHYLLEAD-INDUCED PEROXIDATIVE DAMAGE IN VARIOUS REGIONS OF THE RAT-BRAIN [J].
ALI, SF ;
BONDY, SC .
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH, 1989, 26 (02) :235-242
[2]  
BERDANIER CD, 1988, NUTR REV, V46, P145, DOI 10.1111/j.1753-4887.1988.tb05408.x
[3]   ENZYMATIC FORMATION OF PROSTAGLANDIN E2 FROM ARACHIDONIC ACID PROSTAGLANDINS + RELATED FACTORS 32 [J].
BERGSTROM, S ;
DANIELSSON, H ;
SAMUELSSON, B .
BIOCHIMICA ET BIOPHYSICA ACTA, 1964, 90 (01) :207-&
[4]   RELATIONSHIP BETWEEN FATTY-ACID COMPOSITION OF ERYTHROCYTES AND SUSCEPTIBILITY TO VITAMIN-E-DEFICIENCY [J].
BRIN, M ;
HORN, LR ;
BARKER, MO .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1974, 27 (09) :945-951
[5]  
BROQUIST HP, 1992, NUTR REV, V50, P110
[6]   INVITRO ASSESSMENT OF THE TOXICITY OF METAL-COMPOUNDS .4. DISPOSITION OF METALS IN CELLS - INTERACTIONS WITH MEMBRANES, GLUTATHIONE, METALLOTHIONEIN, AND DNA [J].
CHRISTIE, NT ;
COSTA, M .
BIOLOGICAL TRACE ELEMENT RESEARCH, 1984, 6 (02) :139-158
[7]  
CIRKT M, 1972, BRIT J IND MED, V29, P74
[8]   EFFECT OF LEAD AND NIACIN ON GROWTH AND SEROTONIN METABOLISM IN CHICKS [J].
CUPO, MA ;
DONALDSON, WE .
JOURNAL OF NUTRITION, 1988, 118 (01) :107-113
[9]  
CUPO MA, 1988, DRUG NUTR INTERACT, V5, P297