SYNTHESIS AND BIOASSAY OF A PROTEIN-TYROSINE-PHOSPHATASE INHIBITOR, DEPHOSTATIN

被引：30

作者：

YU, LB

MCGILL, A

RAMIREZ, J

WANG, PG

ZHANG, ZY

机构：

[1] UNIV MIAMI,DEPT CHEM,CORAL GABLES,FL 33124

[2] YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT MOLEC PHARMACOL,BRONX,NY 10461

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 09期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0960-894X(95)00156-N

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of natural product, dephostatin, is described. Both dephostatin and N-methyl-N-nitrosoaniline are found to inactivate the homogeneous recombinant Yersinia and mammalian protein tyrosine phosphatases in a concentration and time dependent manner.

引用

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页码：1003 / 1006

页数：4

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