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DIHYDROFOLATE-REDUCTASE - CONTROL OF THE MODE OF SUBSTRATE BINDING BY ASPARTATE-26

被引：10
作者：
JIMENEZ, MA
ARNOLD, JRP
ANDREWS, J
THOMAS, JA
ROBERTS, GCK
BIRDSALL, B
FEENEY, J
机构：
[1] UNIV LEICESTER,DEPT BIOCHEM,UNIV RD,LEICESTER LE1 7RH,ENGLAND
[2] UNIV MANCHESTER,DEPT PHARM,MANCHESTER M13 9PL,LANCS,ENGLAND
[3] NATL INST MED RES,DIV PHYS BIOCHEM,LONDON NW7 1AA,ENGLAND
来源：
PROTEIN ENGINEERING | 1989年 / 2卷 / 08期
基金：
英国惠康基金;
关键词：
D O I：
10.1093/protein/2.8.627
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：627 / 631
页数：5
相关论文
共 28 条
  • [1] NUCLEOTIDE-SEQUENCE OF THE DIHYDROFOLATE-REDUCTASE GENE OF METHOTREXATE-RESISTANT LACTOBACILLUS-CASEI
    ANDREWS, J
    CLORE, GM
    DAVIES, RW
    GRONENBORN, AM
    GRONENBORN, B
    KALDERON, D
    PAPADOPOULOS, PC
    SCHAFER, S
    SIMS, PFG
    STANCOMBE, R
    [J]. GENE, 1985, 35 (1-2) : 217 - 222
  • [2] A KINETIC-STUDY OF WILD-TYPE AND MUTANT DIHYDROFOLATE REDUCTASES FROM LACTOBACILLUS-CASEI
    ANDREWS, J
    FIERKE, CA
    BIRDSALL, B
    OSTLER, G
    FEENEY, J
    ROBERTS, GCK
    BENKOVIC, SJ
    [J]. BIOCHEMISTRY, 1989, 28 (14) : 5743 - 5750
  • [3] BEDDELL CR, 1984, XRAY CRYSTALLOGRAPHY, P169
  • [4] DIHYDROFOLATE-REDUCTASE - MULTIPLE CONFORMATIONS AND ALTERNATIVE MODES OF SUBSTRATE BINDING
    BIRDSALL, B
    FEENEY, J
    TENDLER, SJB
    HAMMOND, SJ
    ROBERTS, GCK
    [J]. BIOCHEMISTRY, 1989, 28 (05) : 2297 - 2305
  • [5] C-13 NMR EVIDENCE FOR 3 SLOWLY INTERCONVERTING CONFORMATIONS OF THE DIHYDROFOLATE REDUCTASE-NADP+-FOLATE COMPLEX
    BIRDSALL, B
    GRONENBORN, A
    CLORE, GM
    ROBERTS, GCK
    FEENEY, J
    BURGEN, ASV
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1981, 101 (04) : 1139 - 1144
  • [6] NMR-STUDIES OF DIFFERENCES IN THE CONFORMATIONS AND DYNAMICS OF LIGAND COMPLEXES FORMED WITH MUTANT DIHYDROFOLATE REDUCTASES
    BIRDSALL, B
    ANDREWS, J
    OSTLER, G
    TENDLER, SJB
    FEENEY, J
    ROBERTS, GCK
    DAVIES, RW
    CHEUNG, HTA
    [J]. BIOCHEMISTRY, 1989, 28 (03) : 1353 - 1362
  • [7] H-1, C-13, AND P-31 NUCLEAR MAGNETIC-RESONANCE STUDIES OF THE DIHYDROFOLATE-REDUCTASE NICOTINAMIDE ADENINE-DINUCLEOTIDE PHOSPHATE FOLATE COMPLEX - CHARACTERIZATION OF 3 COEXISTING CONFORMATIONAL STATES
    BIRDSALL, B
    GRONENBORN, A
    HYDE, EI
    CLORE, GM
    ROBERTS, GCK
    FEENEY, J
    BURGEN, ASV
    [J]. BIOCHEMISTRY, 1982, 21 (23) : 5831 - 5838
  • [8] N-15 AND H-1-NMR EVIDENCE FOR MULTIPLE CONFORMATIONS OF THE COMPLEX OF DIHYDROFOLATE-REDUCTASE WITH ITS SUBSTRATE, FOLATE
    BIRDSALL, B
    DEGRAW, J
    FEENEY, J
    HAMMOND, S
    SEARLE, MS
    ROBERTS, GCK
    COLWELL, WT
    CRASE, J
    [J]. FEBS LETTERS, 1987, 217 (01) : 106 - 110
  • [9] BLAKELY RL, 1985, FOLATES PTERINS, V1, P191
  • [10] BOLIN JT, 1982, J BIOL CHEM, V257, P13650
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