SOS MUTAGENESIS

被引：45

作者：

MURLI, S ^{[1
]}

WALKER, GC ^{[1
]}

机构：

[1] MIT, CAMBRIDGE, MA 02139 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1993年 / 3卷 / 05期

关键词：

D O I：

10.1016/S0959-437X(05)80089-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In Esherichia coli, UV and many chemicals appear to cause mutagenesis by a process of translesion synthesis that requires some form of DNA polymerase III and the SOS-regulated proteins UmuD, UmuC and RecA. An analysis of SOS mutagenesis offers insights into the molecular basis of induced mutagenesis and into mechanisms of DNA damage tolerance.

引用

页码：719 / 725

页数：7

共 67 条

[61] MUTAGENESIS AND INDUCIBLE RESPONSES TO DEOXYRIBONUCLEIC-ACID DAMAGE IN ESCHERICHIA-COLI [J].

WALKER, GC .

MICROBIOLOGICAL REVIEWS, 1984, 48 (01) :60-93

[62] RECA PROTEIN IN THE SOS RESPONSE - MILESTONES AND MYSTERIES [J].

WITKIN, EM .

BIOCHIMIE, 1991, 73 (2-3) :133-141

[63] LEVELS OF CHROMOSOMALLY ENCODED UMU PROTEINS AND REQUIREMENTS FOR INVIVO UMUD CLEAVAGE [J].

WOODGATE, R ;

ENNIS, DG .

MOLECULAR & GENERAL GENETICS, 1991, 229 (01) :10-16

[64] MUTAGENESIS INDUCED BY BACTERIAL UMUDC PROTEINS AND THEIR PLASMID HOMOLOGS [J].

WOODGATE, R ;

SEDGWICK, SG .

MOLECULAR MICROBIOLOGY, 1992, 6 (16) :2213-2218

[65] UMUC MUTAGENESIS PROTEIN OF ESCHERICHIA-COLI - PURIFICATION AND INTERACTION WITH UMUD AND UMUD' [J].

WOODGATE, R ;

RAJAGOPALAN, M ;

CHI, L ;

ECHOLS, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (19) :7301-7305

[66] CONSTRUCTION OF A UMUDC OPERON SUBSTITUTION MUTATION IN ESCHERICHIA-COLI [J].

WOODGATE, R .

MUTATION RESEARCH, 1992, 281 (03) :221-225

[67] MUTATION HOTSPOTS DUE TO SUNLIGHT IN THE P53 GENE OF NONMELANOMA SKIN CANCERS [J].

ZIEGLER, A ;

LEFFELL, DJ ;

KUNALA, S ;

SHARMA, HW ;

GAILANI, M ;

SIMON, JA ;

HALPERIN, AJ ;

BADEN, HP ;

SHAPIRO, PE ;

BALE, AE ;

BRASH, DE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (09) :4216-4220

← 1 2 3 4 5 6 7 →