SELECTIVITY-ENHANCEMENT OF HYDROLASE REACTIONS

被引：68

作者：

FABER, K

OTTOLINA, G

RIVA, S

机构：

[1] GRAZ UNIV TECHNOL, INST ORGAN CHEM, A-8010 GRAZ, AUSTRIA

[2] CNR, IST CHIM ORMONI, I-20131 MILAN, ITALY

来源：

BIOCATALYSIS | 1993年 / 8卷 / 02期

关键词：

ESTERASE; PROTEASE; LIPASE; SELECTIVITY;

D O I：

10.3109/10242429308998200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review pinpoints the strategies which can be employed to improve the enantio- and diasteroselectivity of hydrolytic enzymes, i.e. esterases, proteases, and lipases. The influence of variations of reactants, - enzyme and substrate - and conditions - kinetics, medium, temperature, pH - on the chiral recognition process of the enzyme is discussed with examples from the recent literature.

引用

收藏

页码：91 / 132

页数：42

相关论文

共 135 条

[71]

JONES JB, 1976, APPLICATIONS BIOCHEM, P133

[72]

Kagan H. B., 1988, KINETIC RESOLUTION, V18, P249

[73]

KAISER ET, 1985, ANNU REV BIOCHEM, V54, P565

[74] RESOLUTION OF BINAPHTHOLS AND SPIROBIINDANOLS USING CHOLESTEROL ESTERASE [J].

KAZLAUSKAS, RJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (13) :4953-4959

[75] A RULE TO PREDICT WHICH ENANTIOMER OF A SECONDARY ALCOHOL REACTS FASTER IN REACTIONS CATALYZED BY CHOLESTEROL ESTERASE, LIPASE FROM PSEUDOMONAS-CEPACIA, AND LIPASE FROM CANDIDA-RUGOSA [J].

KAZLAUSKAS, RJ ;

WEISSFLOCH, ANE ;

RAPPAPORT, AT ;

CUCCIA, LA .

JOURNAL OF ORGANIC CHEMISTRY, 1991, 56 (08) :2656-2665

[76] THERMOSTABLE ENZYMES IN ORGANIC-SYNTHESIS .2. ASYMMETRIC REDUCTION OF KETONES WITH ALCOHOL-DEHYDROGENASE FROM THERMOANAEROBIUM-BROCKII [J].

KEINAN, E ;

HAFELI, EK ;

SETH, KK ;

LAMED, R .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1986, 108 (01) :162-169

[77] RESOLUTION OF RACEMIC MIXTURES VIA LIPASE CATALYSIS IN ORGANIC-SOLVENTS [J].

KIRCHNER, G ;

SCOLLAR, MP ;

KLIBANOV, AM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1985, 107 (24) :7072-7076

[78] UNUSUAL SOLVENT EFFECT ON PROTEASE ACTIVITY AND EFFECTIVE OPTICAL RESOLUTION OF AMINO-ACIDS BY HYDROLYTIC REACTIONS IN ORGANIC-SOLVENTS [J].

KISE, H ;

TOMIUCHI, Y .

BIOTECHNOLOGY LETTERS, 1991, 13 (05) :317-322

[79] ENZYMATIC RESOLUTION OF RACEMIC AMINES - CRUCIAL ROLE OF THE SOLVENT [J].

KITAGUCHI, H ;

FITZPATRICK, PA ;

HUBER, JE ;

KLIBANOV, AM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (08) :3094-3095

[80] REGIOSELECTIVE MODIFICATION OF LYSINES AMINO-GROUPS BY PROTEASES [J].

KITAGUCHI, H ;

ONO, M ;

ITOH, I ;

KLIBANOV, AM .

AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1991, 55 (12) :3067-3073

← 3 4 5 6 7 8 9 10 11 12 →