ACTIONS OF ANESTHETICS ON LIGAND-GATED ION CHANNELS - ROLE OF RECEPTOR SUBUNIT COMPOSITION

被引:177
作者
HARRIS, RA [1 ]
MIHIC, SJ [1 ]
DILDYMAYFIELD, JE [1 ]
MACHU, TK [1 ]
机构
[1] VET AFFAIRS MED CTR,DENVER,CO 80262
关键词
GABA; NMDA; GLUTAMATE RECEPTOR; ALCOHOL; PENTOBARBITAL;
D O I
10.1096/fasebj.9.14.7589987
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Molecular cloning of cDNAs coding for Ligand-gated ion channel subunits makes it possible to study the pharmacology of recombinant receptors with defined subunit compositions, Many laboratories have used these techniques recently to study actions of agents that produce general anesthesia, We review the effects of volatile and intravenous anesthetics on recombinant GABA(A), glycine, AMPA, kainate, NMDA, and 5HT(3) receptors, Evidence for and against specific ligand-gated ion channel subunits as targets responsible for anesthesia or the side effects of anesthetic agents is discussed for each type of receptor, Subunit specific actions of some of the agents suggest that construction and testing of certain chimeric receptor subunits may be useful for defining the amino acid sequences responsible for anesthetic actions.
引用
收藏
页码:1454 / 1462
页数:9
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