STRUCTURE DETERMINATION OF RIBOSYLATED RIFAMPICIN AND ITS DERIVATIVE - NEW INACTIVATED METABOLITES OF RIFAMPICIN BY MYCOBACTERIAL STRAINS

被引：10

作者：

MORISAKI, N

KOBAYASHI, H

IWASAKI, S

FURIHATA, K

DABBS, ER

YAZAWA, K

MIKAMI, Y

机构：

[1] UNIV TOKYO,INST MOLEC & CELLULAR BIOSCI,BUNKYO KU,TOKYO 113,JAPAN

[2] UNIV TOKYO,DEPT AGR CHEM,BUNKYO KU,TOKYO 113,JAPAN

[3] CHIBA UNIV,PATHOGEN FUNGI & MICROBIAL TOXICOSES RES CTR,CHUO KU,CHIBA 260,JAPAN

[4] UNIV WITWATERSRAND,DEPT GENET,JOHANNESBURG 2050,SOUTH AFRICA

来源：

JOURNAL OF ANTIBIOTICS | 1995年 / 48卷 / 11期

关键词：

D O I：

10.7164/antibiotics.48.1299

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Rifampicin (1) was converted into two inactivated products RIP-Ma and RIP-Mb by Mycobacterium smegmatis DSM43756. MS, NMR and chromatographic analysis showed the compounds to be 3-formyl-23-[O-(alpha-D-ribofuranosyl)]rifamycin SV (6) and 23-[O-(alpha-D-ribofuranosyl)]rifampicin (7), respectively.

引用

收藏

页码：1299 / 1303

页数：5

相关论文

共 16 条

[1] CLONING OF NOCARDIOFORM DNA CONFERRING THE ABILITY TO INACTIVATE RIFAMPICIN [J].

ANDERSEN, SJ ;

DABBS, ER .

FEMS MICROBIOLOGY LETTERS, 1991, 79 (2-3) :247-250

[2] RIFAMPICIN INACTIVATION BY BACILLUS SPECIES [J].

DABBS, ER ;

YAZAWA, K ;

TANAKA, Y ;

MIKAMI, Y ;

MIYAJI, M ;

ANDERSEN, SJ ;

MORISAKI, N ;

IWASAKI, S ;

SHIDA, O ;

TAKAGI, H ;

KADOWAKI, K .

JOURNAL OF ANTIBIOTICS, 1995, 48 (08) :815-819

[3] RIBOSYLATION BY MYCOBACTERIAL STRAINS AS A NEW MECHANISM OF RIFAMPIN INACTIVATION [J].

DABBS, ER ;

YAZAWA, K ;

MIKAMI, Y ;

MIYAJI, M ;

MORISAKI, N ;

IWASAKI, S ;

FURIHATA, K .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (04) :1007-1009

[4] RIFAMPICIN INACTIVATION BY RHODOCOCCUS AND MYCOBACTERIUM SPECIES [J].

DABBS, ER .

FEMS MICROBIOLOGY LETTERS, 1987, 44 (03) :395-399

[5]

FURESZ S, 1970, ANTIBIOT CHEMOTHER, V16, P316

[6] FURTHER STUDIES ON ASSIGNMENT OF SIGNALS IN C-13 MAGNETIC-RESONANCE SPECTRA OF ALDOSES AND DERIVED METHYL GLYCOSIDES [J].

GORIN, PAJ ;

MAZUREK, M .

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1975, 53 (08) :1212-1223

[7]

KOBAYASHI H, IN PRESS EXPERIENTIA

[8]

Lancini G, 1977, STRUCTURE ACTIVITY R, P531

[9] RIFAMPICIN - A NEW ORALLY ACTIVE RIFAMYCIN [J].

MAGGI, N ;

PASQUALUCCI, CR ;

BALLOTTA, R ;

SENSI, P .

CHEMOTHERAPY, 1966, 11 (05) :285-+

[10] INACTIVATED PRODUCTS OF RIFAMPICIN BY PATHOGENIC NOCARDIA SPP - STRUCTURES OF GLYCOSYLATED AND PHOSPHORYLATED METABOLITES OF RIFAMPICIN AND 3-FORMYLRIFAMYCIN SV [J].

MORISAKI, N ;

IWASAKI, S ;

YAZAWA, K ;

MIKAMI, Y ;

MAEDA, A .

JOURNAL OF ANTIBIOTICS, 1993, 46 (10) :1605-1610