DISTRIBUTION AND BIOLOGICAL-ACTIVITY OF BETA-THYMOSINS

被引：20

作者：

MIHELIC, M ^{[1
]}

VOELTER, W ^{[1
]}

机构：

[1] UNIV TUBINGEN,INST PHYSIOL CHEM,PHYS ABT,D-72076 TUBINGEN,GERMANY

来源：

AMINO ACIDS | 1994年 / 6卷 / 01期

关键词：

AMINO ACIDS; BETA-THYMOSINS; PHYLOGENETIC DISTRIBUTION; ACTIN SEQUESTRATION; IMMUNOASSAYS; IMMUNOHISTOCHEMISTRY;

D O I：

10.1007/BF00808118

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

beta-Thymosins, a group of highly homologous peptides consisting of about 40 amino acid residues, were found to be distributed from mammals up to echinoderms. Althogh they have first been isolated from mammalian thymus tissue preparations, their occurrance is not organ-specific and they are present even in different types of cells. For thymosin beta(4) several biological activities have been reported, stating that this peptide acts as a thymus peptide hormone and is also involved in the neuroendocrine and immune system. However, it was recently demonstrated that thymosin beta(4) has actin-sequestering properties and therefore might play an important role in the regulation of the microfilament system. This fact gives a new outlook on the real biological function of beta-thymosins.

引用

页码：1 / 13

页数：13

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